NanoplasmidTM Platform for Genetic Payload Optimization
Nanoplasmid Platform Advantages
The Nanoplasmid platform provides several advantages for use as a genetic cargo delivery system.
- Small bacterial region size (< 500 bp)
- Improved manufacturing yields, lower cost
- Reduced toxicity and silencing
- High transgene expression
- Free of antibiotic markers, no residual antibiotics
Nanoplasmids for Viral Vector Production
In addition to the overall advantages of the Nanoplasmid platform, the system has features uniquely suited to rAAV production. Studies have shown that when bacterial sequences are removed during production, as is the case with the Nanoplasmids, "encapsidation of prokaryotic backbone sequences is avoided."1 In addition, the studies showed that transduction efficiency of self-complementary AAV preparations improved up to 30-fold. The Nanoplasmid platform combined with standard AAV packaging protocols can significantly improve the quality of AAV vectors.
RNA-OUT for any plasmid
The RNA-OUT platform is flexible and any plasmid can be modified to use this antibiotic-free selection method. We can design and synthesize your plasmid for any gene therapy application.