RNA Design & Development Headline

Stability starts at the sequence. We fiercely enable your design.

Imagine having access to a comprehensive range of specialized products and services for mRNA production that can significantly reduce supply-chain risks, shorten lead times, and enhance quality. Whether you need enzymes for mRNA synthesis in various configurations—from Research Grade to cGMP drug substance and product—or specific options for capping, tailing, and chemical modification, you can find everything you need to support your program development. mRNA production can begin with an electronic DNA template sequence or supercoiled plasmid DNA provided by the client, supported by process development, scale-up, and analytics required to move your project into clinical trials and beyond.

mRNA Construct Design & Optimization

Aldevron's state-of-the-art quality systems ensure your material meets your specifications. From cloning, verification, restriction digestion, strain selection, cell banking, and plasmid preparation, we meticulously manage every step to guarantee the integrity and efficacy of the mRNA sequence. Whether for research or clinical applications, our commitment to quality ensures the mRNA you receive is of the utmost importance and reliability.

Strain Selection and Optimization

cGMP Master Cell Bank generation

LNP Formulation

LNP formulation is important for long-term success of any RNA drug product. We partner with Cytiva and Acuitas to work with you on LNP formulation. These partnerships and capabilities assure that you have access to all the essentials for mRNA vaccine and therapeutic development, including:

Providing our clients with options, from the simplest starting material to the most complex manufacturing operation, is part of our culture. Our aim is to bring innovation to each step of the journey.

Cloning Backbones

Clone your gene of interest into one of several Aldevron backbones, some with optimized UTRs, for efficient mRNA production.

Alchemy™ Cell-Free DNA

Reduce linear DNA manufacturing times by over 50% and reduce host cell contamination with the Alchemy TM Cell-Free DNA enzymatic manufacturing process

Plasmid DNA & Linearization

Produce phase-appropriate plasmid DNA for research through clinical applications at a variety of scales. Recover 90-95% linear DNA with consistently high poly(A) tails through optimized linearization and purification protocols.

Process Development & Scale Up

Utilize experience gained from over 130 cGMP lots produced for clinical trials and commercial applications to optimize process and scale for each unique molecule.

RNA Drug Substance Manufacturing

Flexible, Scalable process produce high-quality RNA tailored to your specificayions, delivering quantities from milligrams to multi-grams.

RNA Drug Product

Seamless continuation of the RNA drug product manufacturing process, incorporating LNP encapsulation, analytical testing and sterile fill/finish under a single roof and quality system.

Resources

Missing an intro/ overview