mRNA Production with Codex® HiCap Polymerase
Optimize mRNA production from the very start
Aldevron’s RNA manufacturing is now utilizing Codex HiCap as the standard to deliver top quality mRNA with no additional cost
As mRNA programs develop, quantity and quality requirements increase. Starting with production at research grade phase, pure mRNA minimizes unwanted immunogenicity, allowing smoother program progression.
Our research grade mRNA services with Codex HiCap Polymerase offers scalability, raw material and process controls, raw material cost control, and RG-to-cGMP transferability, ensuring consistent quality and affordability.
Using Codex HiCap enzyme in our research grade mRNA production generates fewer undesirable dsRNA byproducts than WT T7 RNA polymerase, reducing unwanted immunogenicity and efficiently incorporating commercially available cap analogs. The result is a superior production of pure RNA for our clients at no additional cost.
mRNA synthesis enzymes
Utilizing our in-house in vitro transcription and capping enzymes, we custom manufacture your research grade mRNA with our NEW Codex HiCap T7 RNA Polymerase. It is a co-transcriptional capping RNA polymerase engineered to produce synthetic RNA to meet increasing demands for safety and cost-effectiveness.
Codex HiCap T7 RNA Polymerase:
- Reduces immunogenic double-stranded RNA (dsRNA) by-products
- Requires up to 62% less cap analog to achieve >95% capping efficiency
- Retained RNA yield and integrity
Scale to the clinic with GMP-Grade Codex HiCap T7 RNA Polymerase
For teams preparing to move from research to clinical development, Codex® HiCap T7 RNA Polymerase is also available in GMP-Grade**. It offers the same performance benefits—reduced dsRNA, efficient capping, and strong yields—now with the quality and compliance needed for regulated manufacturing.
Improve your mRNA manufacturing with the essential starting material. Partner with us today!
| region | na1 |
| portalId | 1769030 |
| formId | 0cf398d8-651d-4ebd-a68e-224851d5ab8d |
| target | services-hubspot-form |
*Codex is a trademark of Codexis, Inc. Any other third-party trademarks are the property of their respective owners.
** “GMP-Grade” is a branding term used by Aldevron to describe products manufactured and released at Aldevron's Madison Innovation campus which operates in compliance with ISO 13485 quality management system standards. Materials under this branding term are intended for further processing as Ancillary Materials, Process Reagents and Raw Materials to produce cell-based and gene therapy products. These materials are neither present in the final product nor administered to humans or animals. It is the sole responsibility of the purchaser and their customers to evaluate the use of GMP-Grade material for their intended use and to ensure compliance with applicable regulatory or legal requirements.