sNLS-SpCas9-sNLS Nuclease

A simple solution from R&D to clinical material

Aldevron provides research grade Cas9 nucleases for use in development work as well as standard GMP products for clinical studies. The concentration for these products is 10 mg/mL, dispensed in the following sizes:

  • Research Grade: 0.25 mg and 5 mg vials 
  • GMP: 10 mg and 50 mg vials


Functional Performance 

  • Ready to use for electroporation, transfections or injection methods
  • Extensive QC panel identical at Research Grade, GMP-S and GMP product levels
  • 10 mg/mL formulation

Manufacturing and Quality Control

  • Research Grade to GMP
  • Consistent activity and purity across all lots

Download CoAs to See QC Specifications

To download your CoAs, please provide your contact information below. We do not share your information with any third parties.

sNLS-SpCas9-sNLS Nuclease Quality Control Specifications

Purity, RP-HPLC  ≥95%
Purity, SDS-PAGE  ≥95%
Aggregation  ≤5% aggregate
Concentration 10.0 mg/mL +/- 10%
Endotoxin  ≤ 10 EU/mg
Residual DNase  < LOQ
Residual RNase  < LOQ
Appearance  Clear, colorless
Residual Host Protein  ≤ 200 ng/mL
Residual Host GenomicDNA  < 1% (w/w)
Activity Assay, in vitro  ≥80% of uncut reference DNA converted to cleavage products
Bioburden  < 2 CFU/Sample
Mycoplasma  Negative for the presence of Mycoplasma


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