Protein Production

Gene-to-protein manufacturing including custom manufacturing, gene editing, and IVT enzymes

At Aldevron, our protein production capabilities range from parallel screening of several constructs through process development optimization, to scale-up manufacturing. Every project starts by defining project goals, including transferring existing protocols or developing a new method.

With experience producing thousands of proteins, we identify potential risks and engineer a solution to meet your required specifications. Responsiveness, technical excellence, and strong project management form the foundation of every strong partnership. It’s our goal to embody those qualities and earn your trust every step of the way.

Custom Protein Services

We manufacture a wide variety of custom proteins including enzymes, growth factors, and nucleases. Aldevron can support Research Grade through GMP for custom protein manufacturing. To fully support in the areas of gene and cell therapy, we have a special focus on the manufacture of gene editing enzymes and ribonucleoproteins. As part of that focus, we are also committed to the production of enzymes that synthesize and cap mRNA.

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Gene Editing

We offer research-grade nucleases manufactured at our ISO13485 facility, which includes SpCas9, SpyFi™, SaCas9, and Cas12a. We also offer GMP-Source and GMP nucleases for SpCas9 and SpyFi. Don't see the enzyme you are looking for? Inquire through our custom protein services.

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IVT Enzymes

We offer research-grade IVT enzymes manufactured at our ISO13485 facility, which include Guanylyltransferase, 2'-O-Methyltransferase, T7 RNA Polymerase , Inorganic Pyrophosphatase, Poly(A) Polymerase, DNase I, and Ribonuclease Inhibitor. Don't see the enzyme you are looking for? Inquire through our custom protein services.

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Applications

Gene Editing Case Study

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Large-batch, high-quality in vitro transcription enzymes are critical to support both R&D as well as commercial production of milligram to gram scale mRNA for gene therapy.

Case Study: Vaccinia Capping Enzyme adds a 7-methylguanylate cap to the 5' of RNA. The enzyme is notoriously difficult to produce recombinantly, resulting in small lot sizes and high cost. To overcome these challenges, we completed an extensive expression and purification method development program. The outcome of the method development was a robust protocol that allows us to cost effectively produce a high-quality Vaccinia Capping Enzyme at the multigram scale.

Gene Therapy Manufacturing Services Matrix

mRNA production for Gene Therapy

Diagnostics Example

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Case Study: copy

Resources