Gene-to-protein manufacturing including custom manufacturing, gene editing, and IVT enzymes
At Aldevron, our protein production capabilities range from parallel screening of several constructs through process development optimization, to scale-up manufacturing. Every project starts by defining project goals, including transferring existing protocols or developing a new method.
With experience producing thousands of proteins, we identify potential risks and engineer a solution to meet your required specifications. Responsiveness, technical excellence, and strong project management form the foundation of every strong partnership. It’s our goal to embody those qualities and earn your trust every step of the way.
Gene Editing Case Study
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Large-batch, high-quality in vitro transcription enzymes are critical to support both R&D as well as commercial production of milligram to gram scale mRNA for gene therapy.Case Study: Vaccinia Capping Enzyme adds a 7-methylguanylate cap to the 5' of RNA. The enzyme is notoriously difficult to produce recombinantly, resulting in small lot sizes and high cost. To overcome these challenges, we completed an extensive expression and purification method development program. The outcome of the method development was a robust protocol that allows us to cost effectively produce a high-quality Vaccinia Capping Enzyme at the multigram scale.