Immunization Strategies

Genetic Immunization

Our core technology, genetic immunization, enables the development of antibodies against any protein target directly from DNA, an electronic sequence, or an accession number.

With this strategy, your target is cloned into one of our proprietary immunization vectors as detailed in your custom target analysis and introduced into the host organism for gene expression.

To help identify positive antisera and hybridomas, screening without purified antigen is made possible with the use of our proprietary screening vectors. As a pioneer in the field, our antibody development team has successfully applied this technology to thousands of target proteins with a very high success rate.

Protein Immunization

Protein immunization enables the generation of antibodies by directly injecting antigens into the host organism. In many cases, our clients have access to purified recombinant proteins that can be used for immunization. If the antigen is not available, we can express and purify your target in different systems (E. coli, insect, mammalian).

Peptide Immunization

Peptide immunization enables the generation of antibodies by directly injecting peptide conjugates into the host organism. As part of our target analysis, we can select linear epitopes as optimal candidates for immunization.

We also offer peptide synthesis and conjugation services for both immunization and screening. Screening can be expanded to include, for example, phosphopeptide specificity for monoclonal development.