Alchemy™ Cell-free DNA Technology

Linear DNA Template for mRNA Production at Research and cGMP Grades

Introducing Aldevron’s new DNA offering - Alchemy cell-free DNA technology. This synthetic DNA technology is a cell-free DNA enzymatic manufacturing process that cuts linear DNA manufacturing time by over 50%, accelerating mRNA development projects with cleaner, safer DNA templates.

Alchemy cell-free DNA technology is now available at research grade to support development and preclinical programs. In addition, a cGMP offering is now available to support clinical applications.

Why Choose Alchemy Cell-free DNA Technology?

Faster Turnaround to Accelerate Your Research

Our Alchemy process significantly reduces production timelines, enabling you to cut your research grade linDNA template production timelines in half.

Embrace the next generation of mRNA manufacturing with Alchemy to expedite your manufacturing timelines and stay ahead in your scientific endeavors.

High Purity with Low Endotoxin and Other Cell-derived Impurities

Using a synthetic cell-free process, we ensure minimal endotoxin and other host cell-derived impurities. This results in higher purity DNA and mRNA downstream.

Comparable activity to traditional linear DNA templates

Our proprietary cell-free DNA manufacturing process, utilizing rolling circle amplification, supports the rapid production of linear DNA templates.

Comparable Quality Control Specifications to Produce mRNA from pDNA

Alchemy-derived templates meet stringent quality control specifications, ensuring that the mRNA produced is of the highest quality. Here are the detailed specifications:

Cleaner and More Efficient

Utilize Alchemy technology for cleaner and more efficient linear templates, ensuring your mRNA is free from E.coli based contaminants and meets the highest standards of purity and performance.

Now Available: cGMP Alchemy Cell-free DNA Technology

Building on the success of our research grade offering, we now provide cGMP grade linear DNA templates using Alchemy cell-free DNA technology. This advancement enables clinical-stage mRNA programs to benefit from the same accelerated timelines and high-purity standards that have transformed preclinical development.

Why Choose cGMP Alchemy?

• Expedited Manufacturing: Shortens cGMP DNA turnaround times by up to 56% compared to traditional plasmid workflows.
• Predictable, Scalable Process: A fully controlled, cell-free enzymatic system eliminates biological variability and supports seamless scale-up.
• Integrated Workflow: Combine cGMP Alchemy with our proven mRNA/LNP capabilities for end-to-end support from template to drug substance.

Frequently asked questions