sNLS-SpCas9-sNLS Nuclease

A simple solution from R&D to clinical material

Aldevron provides Research-grade Cas9 nucleases for use in development work as well as standard cGMP products for clinical studies. The concentration for these products is 10 mg/mL, dispensed in the following sizes:

Research-grade: 0.25 mg and 5 mg vials
cGMP: 1 mg and 10 mg vials

Functional Performance

Ready to use for electroporation or transfection
Extensive QC panels aligned at Research-Grade and cGMP product levels
10 mg/mL formulation

Manufacturing and Quality Control

Research-grade to cGMP
Consistent activity and purity across lots

Download CoAs to See QC Specifications

To download your CoAs, please provide your contact information below. We do not share your information with any third parties.

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sNLS-SpCas9-sNLS Nuclease Quality Control Specifications

Purity, RP-HPLC	≥95%
Purity, SDS-PAGE	≥95%
Aggregation	≤5% aggregate
Concentration	10.0 mg/mL +/- 10%
Endotoxin	≤ 10 EU/mg
Residual DNase	< LOQ
Residual RNase	< LOQ
Appearance	Clear, colorless
Residual Host Protein	≤ 200 ng/mL
Residual Host GenomicDNA	< 1% (w/w)
Activity Assay, in vitro	≥80% of uncut reference DNA converted to cleavage products
Bioburden	< 2 CFU/Sample
Mycoplasma	Negative for the presence of Mycoplasma

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Ordering Information

Product	Pack Size	Catalog Number	RG Purchase Option
SpCas9 Nuclease - RG	0.25 mg	9212-0.25MG	Buy Now
SpCas9 Nuclease - RG	5 mg	9212-5MG	Buy Now

Request cGMP Manufacturing Information

Product	Pack Size	Catalog Number	Purchase Option
SpCas9 Nuclease - cGMP	1 mg	9211-0.1ML	Inquire
SpCas9 Nuclease - cGMP	10 mg	9211-1ML	Inquire

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