Aldevron Breakthrough Blog

A Focus on Analytics, for RNA and Beyond

Driving innovation of industry tools

Analytical innovation is often overlooked in discussions of biotechnology product development and manufacturing processes. For example, in the DNA area, most “state of the art” analytical methods in use were developed in the 1980s, or even earlier. Industrywide, there is a need to continuously innovate in the analytical space due to the tremendous advances in enabling technologies.

Read More

Building an mRNA Ecosystem

Capacity is only part of the solution

During conferences and seminars this year, there has been one particular topic that has come to the fore regarding mRNA production – capacity. Most of the concern comes from the impression that there isn’t enough capacity to meet market demand.

Read More

Don’t Fence Me In

Science, beyond the lab

Science is about connecting. Connecting cause and effect. Connecting molecules and ideas. Connecting with other scientists. It is also about having command of a subject and product, and that may be the most valuable connection of all.

Read More

Comparing Capping

Enzymatic and co-transcriptional capping for RNA

With the manufacture of RNA, capping is one of the many crucial steps in developing the final product. There are two methods of capping, enzymatic and co-transcriptional. Both have advantages and disadvantages.

Read More

A Three-Step RNA Progression

An outlook for mRNA, saRNA and Circular RNA

When mRNA vaccines began to roll out in late 2020 to fight the COVID pandemic, it was the first large-scale use of the molecule after years of research. But the success of those vaccines was only the beginning of new opportunities for the RNA field.

Read More

Webinar on Demand: Advanced Plasmid Technology – Improving Safety and Performance

Nanoplasmid™ Vectors: The Power of Small

In cell and gene therapies, delivery is a critical factor. Regardless of your modality, optimizing payload, impact, and duration are common challenges. Countless programs, globally, are working on the delivery mechanism. However, many have overlooked a key component in improving therapeutic or manufacturing performance: the plasmid.

Read More

Suppliers – You Can’t Live Without Them!

Great relationships and open, honest communication with suppliers can reduce daily pain

These are unprecedented times with challenges we have never seen before. Maintaining a continuous supply of raw materials has become increasingly difficult since the start of the pandemic and with the on-going geopolitical uncertainty. The recent rise in oil prices is also increasing stress on everyone’s supply chains.

Read More

How Did My Project Get So Expensive?

The Hidden Costs of Multiple Tech Transfers

Move fast. Limited funds. Novel ideas. These are consistent themes I’ve noticed in conversations with hundreds of biotechs over the last 20 years, and rightly so. However, these elements sometimes overshadow the need to evaluate the complexities and costs associated with GMP manufacturing in support of a clinical trial, along with what’s needed for manufacturing at phase III and beyond.

Read More

BIO Convention Brings Optimism, Concerns

Timelines and Supply Chains Still Seen as Challenges

BIO International’s annual convention is one of the largest gatherings of biotechnology innovators in the world. The Aldevron team attending this year’s in-person gathering in San Diego observed that the past few years of COVID restrictions haven’t changed the high interest in our industry.

Read More

Connecting on CRISPR

Innovation from the CRISPR 2022 Meeting

When it comes to gene editing technology, there are few meetings as valuable for us and our collaborators as the annual CRISPR meeting. Academic in focus and highly technical in nature, the 2022 edition of this event came to Boston, packing more than 40 lectures and 120 posters into a rapid-fire, three-day learning experience.

Read More