Aldevron Breakthrough Blog
Presentation: Streamlining RNA Capping
August 12, 2026 by Aldevron
Methods to accelerate process development
As mRNA-based vaccines and therapeutics continue to advance, the need for fast, reliable, and practical analytical workflows has become increasingly important. One critical quality attribute in mRNA development is 5’ capping efficiency, which supports RNA stability and efficient translation. Accurately measuring capping efficiency is therefore essential for process development, quality control, and manufacturing readiness.
In her presentation, Streamlining process development of RNA capping using VaxArray® 5’CapQ and HPLC-based methods, Rebecca Young discusses how InDevR’s VaxArray 5’CapQ assay can be used alongside HPLC-based methods to streamline RNA capping process development. The presentation focuses on how high-throughput capping efficiency and integrity analysis can help development teams evaluate more samples, compare process conditions, and make faster, data-driven decisions.
Through case study examples, Young shows how this combined analytical approach can support both enzymatic and co-transcriptional capping workflows, from early R&D through research-grade manufacturing. By pairing the speed of VaxArray 5’CapQ with the detailed confirmation of HPLC-based assays, teams can gain clearer insight into process performance and build a more efficient path toward cGMP manufacturing readiness.
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Aldevron is a premier manufacturing partner, producing high-quality plasmid DNA, mRNA, proteins, and other key components for the development of vaccines, gene and cell therapies, immunotherapies and other treatments. As a part of the Danaher Corporation family of global science and technology companies, Aldevron supports thousands of scientists who are developing revolutionary, lifesaving treatments for millions of people. You can follow the company on LinkedIn, Facebook and YouTube.