Aldevron Breakthrough Blog

Cures and Inspirations

ASGCT highlights transformational approaches

When it comes to large events, the best place to be is front and center. And at the 26th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT) in Los Angeles, that’s where we were, right inside the door in the middle of the exhibition hall. Not only were we able to greet nearly everyone who came to the exhibits, for the first time we joined other Danaher companies in one centralized location, allowing us to jointly highlight the Danaher mission, helping people realize life’s potential, to clients, partners and the industry in general.

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Perspectives: Hold on Tight for the Ride

A crazy, mixed-up world of cell & gene therapy in 2023

News concerning cell and gene therapy (CGT) may make you feel like you are on a rollercoaster. The ride moves very quickly with a lot of ups and downs, plus a few unexpected turns. As we move through 2023, excitement for CGT remains high, but there are lingering concerns about manufacturing and the ability of health care systems to keep up with the science.

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An evolution at TIDES

mRNA joins the mix

In the past, the TIDES USA conference event has been focused on oligonucleotide and peptide therapeutics, providing information on development trends and technologies for those industry segments. That is changing now, with an additional focus on mRNA therapeutics coming into the mix. 

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When Demand Gets Tough, Expansion Gets Going

Ongoing growth in CGT capacity

As the era of genomic medicine gains speed with the innovation of new technologies, we are at the forefront of genetic tools that can prevent, treat, or cure human diseases. It’s an exciting time, as during this early stage in developing new biological drug products, academics and industry are working closely to optimize cell and gene therapies (CGT) for a range of diseases. 

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Advancing through Disruption

Achieving advancement in ATMP regulation through disruptive innovation of European healthcare systems

Partnerships and transformation are a large part of our evolving biotech landscape. Not surprisingly, they were two common themes at this year’s Meeting on the Med in Barcelona.  As an example, attendees discussed how the lack of harmonization across EU member states has led to fragmented access to advanced therapy medicinal products (ATMPs), which varies from country to country. Chris Fox, president of Novartis Gene Therapies, used her company’s product, ZOLGENSMA®, as an example. It’s approved for use in 48 countries but is only accessible in 35. 

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The most important tool to support client success through lead-time reductions

Successful – for both Aldevron and our clients. That is how I would describe Aldevron’s first Shingijutsu Kaizen event and the first Danaher CEO Kaizen event of 2023, held the week of April 10. Not only did the efforts surpass all expectations but it surpassed deliverable goals--success!

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Streamlining the Drug Development Process

Aldevron expands mRNA  production capability

After years of service providers becoming more specialized, we’re now seeing a reversal in that trend. Enterprise offerings and solutions are on the rise, from consumer offerings to huge corporate deals. We can attribute this growth to an increased demand for simplicity of transactions, clear accountability, and building a win-win situation for both parties. 

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Protein Expression for Vaccine Development

Overcoming challenges in process design

Recombinant proteins are an essential component of many vaccines. However, producing these crucial proteins can be challenging. From selecting the appropriate expression system to optimizing fermentation and purification processes, there are many factors to consider when designing a process to make high-quality proteins that can be used for vaccine development.

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Holding It All Together

Encapsulation and mRNA

Imagine trying to hold water in a shape without it being in a container. That essentially summarizes mRNA without encapsulation. mRNA is, by nature, very fragile, so you need to protect it so that it can reach its targeted location when it goes into a body. Without that protection, mRNA will be quickly denatured or hydrolyzed. That’s why encapsulation is so important when developing mRNA-based therapeutics.

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Perspectives: Where do we go from here?

Wide-ranging potential for mRNA vaccines

Overnight success is often the result of years of effort and setbacks, which could be the life story of an mRNA pioneer, Dr. Katalin Karikó, now with the Perelman School of Medicine at the University of Pennsylvania. Karikó spent decades focusing her research on how mRNA could be used for therapies, which ultimately helped lead to the development of COVID-19 vaccines.

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