Aldevron News

Aldevron, Nature Technology Corporation Team up to Offer Nanoplasmids™ for Gene Therapy Manufacturing

Aldevron has announced the immediate availability of NanoplasmidsTM and antibiotic-free RNA-OUT technology for use in gene therapy manufacturing. Through a license agreement with Nature Technology Corporation (NTC), Aldevron can now provide its clients the option of using NTC’s plasmid technology to provide a more efficient system for manufacturing viral vectors used in gene and cell therapy.

Gene and cell therapy companies interested in using NTC’s technology can now go directly to Aldevron for their manufacturing needs without first obtaining a license from NTC. For applications where the NTC plasmid is not the active pharmaceutical ingredient or in the final product clients do not need to pay any royalties or license fees beyond the purchase price of the product.

“Gene and cell therapy researchers continue to make incredible discoveries that will improve lives for millions of people,” said Michael Chambers, Aldevron CEO. “Aldevron is committed to providing the best manufacturing technologies to support their breakthrough treatments. Our partnership with NTC enables us to provide plasmid technology that significantly improves the manufacturing process and reduces regulatory risk, resulting in reduced costs and faster time to patients.”

The fields of gene and cell therapy are surging with the approvals of KymriahTM and YescartaTM CAR-T treatments for cancer and LuxturnaTM for the treatment of Leber congenital amaurosis, a rare genetic ocular disease. With nearly 3,000 clinical trials underway, improvements in manufacturing are required to provide the capacity to accommodate the growth in research and anticipated commercial products. The NTC technology, combined with Aldevron’s unequaled scale and throughput, assure clients will have the products they need.

“Our Nanoplasmid and RNA-OUT technology has been under development for 12 years and can provide demonstrable advantages for viral vector manufacturing,” said Clague Hodgson, CEO of NTC. “We are pleased to collaborate with Aldevron to make this technology immediately available to its clients so they can avoid the delay and expense associated with the licensing process thereby reducing the barriers to delivering transformative treatments to patients.”

“Providing these novel plasmids furthers our strategy to go beyond the traditional role of a contract development and manufacturing organization,” added Chambers. “Aldevron provides a variety of options for clients, including off-the-shelf, royalty-free helper plasmids for AAV production and packaging plasmids for lentiviral production, in pursuit of our goal to enable our clients to make a difference in the lives of the patients they serve.”

About Nature Technology Corporation
Nature Technology Corporation is a developer of safe and effective nucleic acid-based gene therapeutics, DNA vaccines, and associated technologies, including antibiotic-free selection (RNA-OUT), regulatory compliance, viral vector retrofitting, and best in class NanoplasmidsTM. NTC proprietary vector and manufacturing platforms offer wide applications to improve the safety and performance of plasmids and biologics. NTC also provides cost effective outsourcing of product development services including custom gene design, vector construction, plasmid DNA manufacturing and recombinant proteins. For more information about NTC products and business related inquiries, visit or contact Deborah Moorad-Watts by email at

Topics: Gene Therapy, Partnerships