Aldevron and Integrated DNA Technologies, Inc. (IDT), a supplier of custom nucleic acid and genome editing products, have announced a license agreement whereby Aldevron will manufacture and distribute a S. pyogenes Cas9 variant—known as SpyFiTM Cas9 Nuclease—which is patented by IDT. The product will be manufactured for research, clinical, and commercial use.
“IDT continues to be an innovator for the biotechnology industry. We are excited to expand our partnership,” said Michael Chambers, Aldevron CEO. “This license will accelerate gene editing programs and help bring transformative treatments to patients. Aldevron’s 20 years of experience manufacturing biological material will allow us to provide our clients with SpyFi Cas9 Nuclease for use in research studies, clinical trials, and commercial applications.”
Mark Behlke, M.D., Ph.D., Chief Scientific Officer at IDT, added, “A significant amount of development effort went into making a S. pyogenes HiFi Cas9 mutant that worked in ribonucleoprotein formats, compatible with use in ex-vivo clinical protocols. We are excited to expand our collaboration with Aldevron to make available a full GMP version of this novel protein and to better serve the biomedical community, in addition to our traditional research markets.”
An advisory panel at the National Institutes of Health recently approved the first clinical trial using CRISPR-Cas9, which is planned to start by the end of the year. The project uses gene editing to augment cancer therapy by modifying a patient’s T cells. The technique has the potential to become a significant treatment in a wide variety of diseases.
Aldevron will have research grade SpyFi Cas9 nuclease available for shipment in December 2017. The company anticipates clinical grade SpyFi Cas9 Nuclease to be available in Q4 2018.
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Aldevron serves the biotechnology industry with custom production of nucleic acids, proteins, and antibodies. Thousands of clients use Aldevron-produced plasmids, RNA and gene editing enzymes for projects ranging from research grade to clinical trials to commercial applications. Aldevron specializes in GMP manufacturing and is known for inventing the GMP-SourceTM quality system. Company headquarters are in Fargo, N.D., with additional facilities in Madison, Wisc., and Freiburg, Germany.
Integrated DNA Technologies, Inc. (IDT) is the world leader in delivering custom nucleic acid products for the life sciences market in the areas of academic research, medical diagnostics, biotechnology, agriculture, and pharmaceutical development. The company's primary business is the production of custom oligonucleotides for molecular biology applications. IDT has developed proprietary technologies for genomics applications, such as next generation sequencing, CRISPR genome editing, qPCR, and RNA interference. Through its GMP services, IDT manufactures products used in diagnostic tests for cancer and most inherited and infectious diseases. For more information, please visit www.idtdna.com or contact Gwen Rosenberg, Vice President, Global Corporate Communications, at firstname.lastname@example.org.