Plasmid DNA for research, preclinical, and clinical applications scaled to fit projects of any size
Aldevron has been perfecting plasmid DNA production for more than 20 years, using proprietary technology to manufacture DNA for a wide range of research, preclinical, clinical, and diagnostic applications.
Whether you require 1mg of DNA for a research study or 100 g for a clinical trial, our goal is to provide you with the most affordable, high-quality plasmid DNA manufacturing services that meet your requirements.
Pure, high-quality plasmid DNA is critical for a successful transfection. Our high-purity, high-homogeneity, low-endotoxin plasmid DNA is ideal for any transfection application.Case Study: A client suffered from very low plasmid production yields using other vendors. Our optimization resulted in a 9X increase in the yield per liter of media. In addition, the purity far exceeded that of previous manufacturing attempts.
From ITR-bearing cis-plasmids to very large helper plasmids, our manufacturing technology produces high yields even for the most difficult constructs.Case Study: A client required 95% monomer plasmid DNA as the final deliverable. The starting material provided was predominantly dimerized/multimeric. Our team linearized the material, ligated it back together to create the monomer, and transformed. We achieved the required specification for both the supercoiled and linearized plasmid DNA deliverable.
In vivo studies for DNA vaccines
With a consistent manufacturing process from research grade through clinical production, we ensure reliable, high-quality DNA for your vaccine program.Case Study: When West Nile virus threatened the survival of endangered condors in California, we were contracted to manufacture a DNA vaccine developed by the Centers for Disease Control and Prevention. Our production and quality control systems allowed us to manufacture the vaccine in less than two months. The vaccine went on to protect other endangered species against West Nile virus.
Whether your application is a messenger RNA therapeutic or guide RNA for CRISPR-Cas9, we have extensive experience producing linearized plasmid DNA using a variety of enzymes with advanced purification techniques.Case Study: A client required a high yield and consistent poly(A) tail length for their template. We evaluated a variety of resin and buffer combinations as well as post-linearization purification strategies. The result was 90-95% recovery of linearized DNA with a consistently high poly(A) tail length.