Human Antibodies from Aldevron and Trianni, Inc.
Expressing full human antibodies for therapeutic discovery
The Trianni MouseTM embodies powerful, next-generation platform technology enabling efficient generation of fully-human monoclonal antibodies. This transgenic mouse carries a complete human antibody repertoire, including highly engineered versions of all three antibody-encoding genetic loci (Heavy, Kappa, and Lambda), in a single organism.
Generated using state-of-the-art DNA synthesis and genome modification methodology, Trianni mice take advantage of processes that “screen” antibodies for heavy chain and light chain compatibility, robust expression and target selectivity in vivo.
Importantly, only the exons encoding the variable-domain sequences in the mouse have been replaced by their counterpart human exon sequences. All of the remaining Ig sequence is of mouse origin, including promotor, enhancer and other regulatory elements. Fully-human therapeutics can be generated from resulting chimeric repertoires through standard cloning methodology.
Hybridoma and/ or B-cell cells are delivered for every antibody project. We also provide the following complementary services:
- Antibody sequencing
- Recombinant antibody production
- Antibody purification from hybridomas
Complete our online form for a complimentary antibody target analysis.