Ready-to-use rAAV helper plasmid
Triple transfection is the most common method for rAAV production and does not require co-infection with adenovirus. The process requires the cis plasmid encoding the transgene, a plasmid for AAV rep and cap genes in trans, and the helper plasmid encoding the required adenoviral helper genes.
With Aldevron's pALD-X80, clients do not need to manufacture a custom batch of the helper plasmid. It can be purchased as an off-the-shelf product, reducing timeline and cost. In addition, pALD-X80 includes kanamycin resistance, an alternative to ampicillin acceptable to regulatory agencies.
A solution from early research through commercial development
pALD-X80 is available in three quality grades: Research, GMP-SourceTM and GMP. Clients have the option of choosing the quality grade that fits their needs and stage of development with the assurance that the royalty-free product will be available when they need it.