Aldevron Breakthrough Blog

Taking biotech as far as it can go at the Breakthrough Symposium

Aldevron is privileged to work with some of the most innovative and groundbreaking companies, academic institutions, and government laboratories in biotechnology today. Since the company’s founding 20 years ago, Michael Chambers and John Ballantyne have always focused on clients, with the goal to improve the lives of the customers and patients they serve. Researchers across the globe are making tremendous breakthroughs in gene and cell therapy and gene editing, resulting in advances in medicine, agriculture, energy and many other fields. We are honored to serve as the basis for many of these transformative products.

Read More

Advancing therapies with mRNA

The idea of using messenger RNA (mRNA) as a drug or vaccine has interested scientists for decades. It transiently passes genetic information to the protein factories inside our cells, and can be engineered to tell this machinery what to make to fight, or prevent, disease.

Read More

Advancing opportunity in cell-based immunotherapy

Both immunotherapy and regenerative medicine are experiencing explosive growth.  It was a pleasure to learn about the advancements in these fields at two excellent conferences, the CAR-TCR Summit organized by Hanson Wade, and the Cell and Gene Meeting on the Mesa sponsored by the Alliance of Regenerative Medicine.

Read More

One Health: A connection between people and animals

When we talk about One Health, just what do we mean? On its own, the phrase can be interpreted to mean many things, but for what we do in the biotechnology field, it encompasses human and animal health and disease, along with related environmental and epidemiological components. Essentially, it defines how people and animals interact with, and within, our shared environments, especially in reference to health and developing treatments for diseases.

Read More

Growing agricultural productivity with CRISPR-Cas9

When we talk about the use of CRISPR-Cas9 technology, it’s usually in the context of developing treatments for human diseases. But there’s another aspect to the technology that has potential to have just as much impact on our lives: its use in the genetic modification of food crops. 

Read More

Helping create future scientists

We never know where roads will lead us, though one roadmap we’re proud of providing is one of internships, helping develop scientific talent in our growing biotechnology industry.

It is great to be able to provide the opportunity and watch students getting involved in the industry while being able to apply what they are learning at college to the work going on in the field. 

This is a benefit to them, our company and the industry at large, as they will be the next generation of scientific talent helping drive breakthroughs in research and providing novel health care.

Read More

Efficient, reproducible results with Cas9

By Krishanu Saha, Ph.D., Department of Biomedical Engineering & Wisconsin Institute for Discovery, University of Wisconsin-Madison

At the University of Wisconsin - Madison, one focus of our group is understanding and optimizing CRISPR-Cas9 gene editing for therapeutic and disease modeling applications. To conduct our research, we need reliable, consistent and highly efficient Cas9 protein.

Model system for Cas9 gene editing
To perform targeted gene editing, the Cas9 protein, which cuts the genome, and a guide RNA (gRNA) that encodes where in the genome to cut, need to be complexed together into a ribonuclear protein (RNP) complex and transfected to cells to reach the nucleus. Once the DNA is cut, imprecise DNA repair may cause disruption at the cut site, which can result in knock out of a gene.

Read More